Iron-catalyzed Alkyl–Alkyl Negishi Coupling of Organoaluminum Reagents

Iron-catalyzed homo-coupling of simple and functionalized arylmagnesium reagents.

Iron-catalyzed homo-coupling of simple and functionalized arylmagnesium reagents is described. The reaction is highly chemoselective (CN, COOEt and NO(2) groups are tolerated). The procedure was used to perform intramolecular couplings. This cyclization reaction is the key step of the total synthesis of the N-methylcrinasiadine.

Palladium-Catalyzed Alkenylation by the Negishi Coupling

Ligand-Free Copper-Catalyzed Negishi Coupling of Alkyl-, Aryl-, and Alkynylzinc Reagents with Heteroaryl Iodides.

Reported herein is an unprecedented ligand-free copper-catalyzed cross-coupling of alkyl-, aryl-, and alkynylzinc reagents with heteroaryl iodides. The reaction proceeds at room temperature for the coupling of primary, secondary, and tertiary alkylzinc reagents with heteroaryl iodides without rearrangement. An elevated temperature (100 °C) is required for aryl-heteroaryl and alkynyl-heteroaryl ...

Palladium catalyzed coupling of organotin reagents

A novel, synthetically useful palladium catalyzed cross-coupling reaction of organotin reagents with a variety of organic electrophiles that generates a new carbon—carbon bond has been discovered recently. Because this mild, versatile reaction is tolerant of a wide variety of organic functionality on either coupling partner, is stereospecific, and gives high yields, it is ideal for use in the s...

Iron-catalyzed alkylations of aromatic grignard reagents.

Significance: The development of iron-catalyzed cross-coupling reactions is an extremely promising field of research, taken into account the importance of this method for current organic synthesis and the multiple problems connected with commonly used Pdand Ni-catalyzed processes. The group of Cahiez reported the first iron-catalyzed alkyl–aryl cross-coupling reaction, suitable for industrial l...